Synaptic Imaging Plasticity

The aim of our research is to study how synaptic transmission and plasticity of synaptic contacts changes during key periods of development or via pharmacological manipulation in the hippocampus and cortex. Furthermore, to gain an understanding into the underlying mechanisms of the changes observed in information processing disorders, such as intellectual disability, at both the cellular and network levels in the brain.

RESEARCH FOCUS

The aim of our research is to study how synaptic transmission and plasticity of synaptic contacts changes during key periods of development or via pharmacological manipulation in the hippocampus and cortex. Furthermore, to gain an understanding into the underlying mechanisms of the changes observed in information processing disorders, such as mental retardation, at both the cellular and network levels in the brain.

In our department at the VU Amsterdam, we use patch-clamp and multi-electrode electrophysiological techniques to study neuronal and synaptic function both at single-cell and circuit levels within the nervous system. In addition, we combine this with multi-photon microscopy for imaging calcium transients and spine morphology in vitro.

For regular updates, see www.rhisearch.com


Sensitive and critical periods during neurotypical and aberrant neurodevelopment: a framework for neurodevelopmental disorders (2015) RM Meredith. Neuroscience & Biobehavioral Reviews, 50:180-8. doi: 10.1016/j.neubiorev.2014.12.001.

La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C. (2014) FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nat Neurosci. 17(12):1693-700. doi: 10.1038/nn.3870.

Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses. MB Verhoog, N Goriounova, G Testa-Silva, J Obermayer, J Stroeder, C PJ de Kock, JC Baayen, RM Meredith, HD Mansvelder (2013). J Neurosci 33(43):17197-208.

MR Groen, O Paulsen, E Perez-Garci, T Nevian, J Wortel, MP Dekker, HD Mansvelder, A van Ooyen*, RM Meredith* (2014) Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons. J Neurophys 112(2):287-99.

Team Leader
Rhiannon Meredith