Team Leader
Huib Mansvelder

Cortical microcircuits

We want to understand how events at the synaptic and cellular levels are involved in behaviour. To reach this goal, we take a multidisciplinary approach in which we combine electrophysiological recordings and imaging from single neurons and networks of neurons with behaviour. By using molecular interventions, optogenetics and assessing the consequences at different levels of organization, we try to get an understanding of the causal relationships between activity of synapses, neurons, neuronal networks, and cognitive behavior. In collaboration with the Neurosurgery department at the VU medical centre, we study the function of human neuronal circuits to test whether basic principles discovered in rodents hold in human cortical microcircuits.

Team Leader
Christiaan de Kock

In Vivo Neurophysiology

We study how individual cortical neurons encode sensory stimuli and how sensory representation is affected by behavior. The rodent barrel cortex is an excellent system to study these questions since the individual sensory organs (facial whiskers) are represented by easily identifiable cortical columns. Additionally, our group is part of an international effort to understand human brain function at (sub)cellular resolution.

Team Leader
Klaus Linkenkaer-Hansen

Neuronal Oscillations and Cognition

We aim to understand the role of neuronal oscillations for cognition in health and disease.

Team Leader
Rhiannon Meredith

Synaptic Imaging Plasticity

The aim of our research is to study how synaptic transmission and plasticity of synaptic contacts changes during key periods of development or via pharmacological manipulation in the hippocampus and cortex. Furthermore, to gain an understanding into the underlying mechanisms of the changes observed in information processing disorders, such as intellectual disability, at both the cellular and network levels in the brain.

Team Leader
Eus van Someren

Sleep and Cognition

The Sleep & Cognition group of Eus van Someren and Ysbrand van der Werf works at several locations, including their home base of Netherlands Institute for Neuroscience (KNAW), the VU University (FALW-Integrative Neurophysiology), the VUmc (Dept. Anatomy and Neurosciences) and the Leiden University Medical Center (Sleep Center Leiden). Against the background of their 24-hour rhythm, driven by the circadian clock of the brain, sleep and wakefulness show a mutual dependency.

Team Leader
Pieter Roelfsema

Vision & Cognition

The Vision and Cognition group is led by Pieter Roelfsema, also director of the Netherlands Institute for Neuroscience. Research of this group is directed at understanding cortical mechanisms of visual perception, memory and plasticity. One of our goals is to create a visual cortical prosthesis to restore vision in blind people.

Team Leader
Rogier Min

Glial (patho)physiology

We study the interactions between neurons and glial cells, both in the healthy brain and in the context of neurological diseases. In particular we focus on the white matter disease MLC, a disease characterized by dysfunctional astrocyte water and ion homeostasis leading to chronic white matter oedema. Our team is embedded in both the VU University medical center (Department of Childhood Neurology headed by Prof. Marjo van der Knaap) and the CNCR (Department of Integrative Neurophysiology headed by Prof. Huibert Mansvelder).